Medicinal Chemistry
News and Events - 2009


September - November

Longqin Hu received a grantentitled "Optimization of EphA subtype-selective antagonists as probes for the nervous system" from National Institute of Health (NIAAA).

G.S. Minhas, D.S. Pilch, J.E. Kerrigan, E.J. LaVoie, and J.E. Rice, Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles. Bioorg. Med. Chem. Lett., 16(15), 3891-3895, 2006 was recognized as being in the "Top-50 most cited articles" as published in Bioorganic and Medicinal Chemistry Letters between 2006 and 2009.

Dr. Joseph Rice has been reelected as the graduate director for the Medicinal Chemistry Department.  This position will be for a commitment of three years.

Tsai, Y-C., Qi, H., Lin, C-P., Lin, R-K., Kerrigan, J., Rzuczek, S.G., LaVoie, E.J., Rice, J.E., Pilch, D.S., and Liu, L.F.,  A G-quadruplex stabilizer induces M phase cell cycle arrest. J. Biol. Chem., 284(34), 22535-22543, 2009.
 
Xinghua Wu, Yu Chen, and Longqin Hu* An improved practical synthesis of protected <alpha>-amino selenocarboxylates and its application to the synthesis of N-(<alpha>-aminoacyl)sulfonamides. Tetrahedron Lett.2009, 50(40), 5585-5588.

June

Dr. Edmond LaVoie served as the Chairperson of the drug discovery section of the 2009 AACR Program Committee to review and grade abstracts to be presented from April 18 to April 22, 2009, at the AACR Annual Meeting in Denver.

The Department of Medicinal Chemistry cosponsored, with the Tri-State Chinese American Chemical Society (CACS), the 2009 CACS Annual Spring Symposium in Busch Campus Center on June 13, 2009. The theme of this year's symposium was " Innovation and Entrepreneurships in Pharmaceutical and Chemical R&D," which attempted to reflect some of the current industry trends in combating the economic downturn. The symposium was attended by approximately 200 people and featured talks by a group of distinguished speakers that included Dr. Gregory J. Szpunar, Senior Vice President of Pharmaceutical Sciences and Drug Metabolism of Schering-Plough Research Institute, Dr. Arthur A. Andrews, Vice President of Global Drug Product Development of Johnson & Johnson Pharmaceutical R&D, Dr. Paul Juniewicz, Senior Vice President & Head for Global External Innovation Access, sanofi-aventis, and Dr. Nilesh Shah, Research & Development Director, Household & Personal Care, Dow Advanced Materials. In addition, an introduction to ACS Diversity Partner Program was presented by Dr. Guang Cao of Exxon Mobile with a focus on Asian chemical professionals.

Dr. Longqin Hu has been promoted to Professor I.

 Yongying Jiang, Robert S. DiPaola, and Longqin Hu* Synthesis and stereochemical preference of peptide 4 aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA). Bioorg. Med. Chem. Lett.2009, 19(9), 2587-2590.

Auemduan Prawan, Constance Lay Lay Saw, Tin Oo Khor, Young-Sam Keum, Siwang Yu, Longqin Hu and Ah-Ng Tony Kong* Anti-NF- KB and anti-inflammatory activities of synthetic isothiocyanates: Effect of chemical structures and cellular signaling. Chem. Biol. Interact. 2009, 179(2-3), 202-211.

March

Renovations to rooms 305 and 307 (ventilation, electrical, and air compressor) were completed in mid-January.  The new Bruker AVIII 400 MHz NMR spectrometer was installed in late January and is up and running and is being heavily utilized by the various research groups.

Yiyu Ge, Xinhua Wu, Dazhi Zhang, and Longqin Hu*  3-Aminoxypropionate-based linker system for cyclization activation in prodrug design.  Bioorg. Med. Chem. Lett.2009, 19(3), 941-944.

Yu Chen and Longqin Hu*  Design of targeted anticancer prodrugs for reductive activation. Med. Res. Rev.2009, 29(1), 29-64.

Yongying Jiang and Longqin Hu* N-(2,2-Dimethyl-2-(o -nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard. Bioorg. Med. Chem. Lett.2008, 18(14), 4059-4063.

Xumu Zhang, “Practical Asymmetric Hydrogenation and  Hydroformylation Reactions” Suzhou University,  Suzhou,  China, Nov. 27, 2008; Shanghai,  China, Dec. 2, 2008; Wuhan,  China, Dec. 4, 2008; Beijing,  China, Dec. 8, 2008; Nankai University,  China, Dec. 10, 2008.


February

The new Bruker Avance 400 MHz NMR Spectrometer was delivered in January and is now operational. The instrument features a smart BACS Automated 60 Sample Changer, variable temperature capability, a multi-nuclear probe, and a triple resonance probe. This instrument was purchased using funds from NIH Shared Instrumentation Grant 1S10RR023698-01A1.

Dr. Joel Freundlich will join the Medicinal Chemistry Department at the beginning of March as a Visiting Professor. Dr. Freundlich comes to Rutgers from Princeton University.

The Rutgers University Board of Governors gave its final approval for the change in name of our department to the Department of Medicinal Chemistry.