Medicinal Chemistry
News and Events - 2008


August

The Graduate Program in Medicinal Chemistry is happy to welcome three new full-time incoming Ph.D. students:

Congratulations to the following students who recently graduated from the Medicinal Chemistry program:

Professor Longqin Hu served on the 2008 Clinical and Experimental Therapeutics 4 (CET-4) Peer Review Panel for the DOD Breast Cancer Research Program, Reston, VA, July 13-15, 2008.  

Yu Chen and Longqin Hu* Design of anticancer prodrugs for reductive activation. Med. Res. Rev.2008, Published Online: 7 Aug 2008.

Yongying Jiang and Longqin Hu* N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard. Bioorg. Med. Chem. Lett.2008, 18(14), 4059-4063.

Mavurapu Satyanarayana, Suzanne G. Rzuczek, Edmond J. LaVoie , Daniel S. Pilch, Angela Liu, Leroy F. Liu and Joseph E. Rice, Ring-Closing Metathesis for the Synthesis of a Highly G-Quadruplex Selective Macrocyclic Hexaoxazole Having Enhanced Cytotoxic Potency, Bioorg. Med. Chem. Lett., 18, 3802-3804, 2008.

Daniel S. Pilch, Christopher M. Barbieri, Suzanne G. Rzuczek, Edmond J. LaVoie and Joseph E. Rice, Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds, Biochimie , 90, 1233-1249, 2008.

Mavurapu Satyanarayana, Wei Feng, Liang Cheng, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, and Edmond J. LaVoie, Syntheses and Biological Evaluation of Topoisomerase I-Targeting Agents Related to 11-[2-N,N-dimethylaminoethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H -isoquino[4,3-c]cinnoline-12-one (ARC-31), Bioorg. Med. Chem., 16, 7824-7831, 2008.

Wei Feng, Mavurapu Satyanarayana, Yuan-Chin Tsai, Angela A. Liu, Leroy F. Liu, and Edmond J. LaVoie, Facile formation of hydrophilic derivatives of 5H -8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxydibenzo[ c,h][1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates, Bioorg. Med. Chem. Lett 18, 3570-3572, 2008.

Professor Longqin Hu presented a talk entitled “Design of Novel Anticancer Prodrugs for Site-Specific Activation and Delivery in Tumor Tissues” at The 4th Sino-US Chemistry, Professors Conference, June 12-13, 2008, Beijing, China.

Yu Chen, Kumar Pabbisetty , Dimitar Nikolov, and Longqin Hu Design and synthesis of peptidomimetics as potential EphB2 antagonists. Abstracts of Papers, 236 th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008, MEDI-351.

Yiyu Ge, Xinghua Wu, Dazhi Zhang, Lin Chen, and Longqin Hu 3-Aminoxypropionate-based linker system for cyclization activation in prodrug design. Abstracts of Papers, 236 th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008, MEDI-401.

Xinghua Wu, Yu Chen, and Longqin Hu A novel synthesis of chromogenic/fluorogenic amino acid conjugates of p-nitroaniline and 7-amino-4-methylcoumarin. Abstracts of Papers, 236 th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008, ORGN-654.

Suzanne G. Rzuczek, Daniel S. Pilch, Angela Liu, Leroy F. Liu, Edmond J. LaVoie, and Joseph E. Rice Macrocyclic Polyoxazoles As Selective G-Quadruplex Stabilizers, 236th ACS National Meeting & Exposition, August 17-21, 2008, Philadelphia, PA, USA.

Mavurapu Satyanarayana, Suzanne G. Rzuczek, Daniel S. Pilch, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie, and Joseph E. Rice Ring-Closing Metathesis As An Entry Into Cytotoxic Macrocyclic Polyoxazoles, , 236th ACS National Meeting & Exposition, August 17-21, 2008, Philadelphia, PA, USA.

Wei Feng, Satyanarayana Mavurapu, Yuan-chin Tsai, Angela Liu, Leroy F. Liu, and Edmond J. LaVoie    11- and 12-Substituted 2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine Derivatives as Novel Topoisomerase I-Targeting Antitumor Agents, , 236th ACS National Meeting & Exposition, August 17-21, 2008, Philadelphia, PA, USA.

Mavurapu Satyanarayana, Wei Feng, Liang Cheng, Angela A. Liu, Yuan-chin Tsai, Leroy F. Liu, Edmond J. LaVoie, Facile Formation of Hydrophilic Derivatives of 11-[2-(N,N-dimethylamino)-ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31) and Its 11-Deaza Analog, ARC-111, , 236th ACS National Meeting & Exposition, August 17-21, 2008, Philadelphia, PA, USA.

Edmond J. LaVoie,Introduction to Natural Products Chemistry, Rutgers University International Training Program on Natural Products, New Brunswick, NJ USA August 11-15, 2008.

Edmond J. LaVoie,Biodisposition of Natural Products and GI Distress, Rutgers University International Training Program on Natural Products, New Brunswick NJ, USA, August 11-15, 2008.

LaVoie, E. J., Rice, J. E., Satyanarayana, M. , THERAPEUTIC COMPOUNDS, This application claims priority from U.S. Provisional Application Number 60/953660, filed 2 August 2007, which application is incorporated by reference.

LaVoie, E. J. and Rice, J. E., THERAPEUTIC COMPOUNDS, This application claims priority from U.S. Provisional Application Number 60/953648, filed 2 August 2007, which application is incorporated by reference.

February

Dr. Joseph Rice has been awarded a NCRR Shared Instrumentation Grant (SIG) in the amount of $351,400 for the Purchase of a 400 MHz Multi-Nuclear NMR Spectrometer to be housed in room 307. 

Professor Longqin Hu served on the Targeted Therapeutics 1 (TT-1) Peer Review Panel for the Komen for the Cure Foundation, Alexandria, VA, January 8-9, 2008.

Suzanne G. Rzuczek , Daniel S. Pilch, Edmond J. LaVoie, and Joseph E. Rice, Lysinyl Macrocyclic Hexaoxazoles: Synthesis and Selective G-Quadruplex Stabilizing Properties. Bioorganic and Medicinal Chemistry Letters, 18(3), 913-917, 2008.

Dr. Edmond J. LaVoie has been issued patent #7319105  on 1/15/08 for "Cytotoxic Agents"

January

Professor Xumu Zhang presented a talk at the Southwest Regional American Chemical Society meeting in Lubbock Texas, November 4-7, 2007.