Medicinal Chemistry
News and Events - 2007


October

Dr. Edmond J. LaVoie “Drug Discovery in Academia: Marketed Drugs from Academia”, PHARMACEUTICS CONFERENCE 2007, at the Hyatt Regency , New Brunswick, NJ October 5, 2007.

September

Yongying Jiang, Zhoupeng Zhang, Robert S. DiPaola, and Longqin Hu* Synthesis and epimerization of phenylalanyl 4-aminocyclophosphamides. Tetrahedron2007, 63(43), 10637-10645.

Dr. Xumu Zhang was an invited speaker at Department of Chemistry & Biochemistry, University of Oklahoma, OK, September 12 14, 2007.

August

The Graduate Program in Medicinal Chemistry is pleased to welcome eight new students for the Fall 2007 semester:

Herve Aloysius, B.S. Biochemistry, University of British Columbia; M.S. Pharmacy, University of British Columbia
Chaoxian Cai, B.S. Chemistry, Beijing University; M.S. Chemistry, University of Kentucky
Lin Chen, B.S. Pharmacy, Congqing University Medical School, China; M.S., Medicinal Chemistry, Shanghai Jiao Tong University, China
Jason Hoar, B.S. Chemistry, Penn State University
Ashish Kumar, B.S. Pharmacy, International College, India
Justin Lopchuk, B.S. Chemistry and Biology, Muhlenberg College
Maria Meija, B.S. Chemistry, Cook College, Rutgers University
Daniel Rimoldi, B.S. Biochemistry, Ramapo College of New Jersey

Professor Longqin Hu served on the 2007 Clinical and Experimental Therapeutics 4 (CET-4) Peer Review Panel for the DOD Breast Cancer Research Program, Alexandria, VA, August 15-17, 2008.

Dr. Xumu Zhang presented a seminar at the Department of Chemical Biology through the Carcinogenesis & Chemoprevention Program of CINJ.   The title of his talk was Practical synthesis of Chiral Pharmaceutical Products, Rutgers Laboratory for Cancer Research, Piscataway, NJ, July 20, 2007.

July

Yiyu Ge and Longqin Hu Microwave-assisted deformylation of N-aryl formamide by KF on basic Al2O3. Tetrahedron Lett., 48(26), 4585-4588, 2007.

Kumar B. Pabbisetty, Xin Yue, Chen Li, Juha-Pekka Himanen, Renping Zhou, Dimitar B. Nikolov, and Longqin Hu Kinetic analysis of binding of monomeric and dimeric ephrins to Eph receptors: correlation to function in a growth cone collapse assay. Protein Sci., 16(3), 355-361, 2007.

Professor Longqin Hu received a grant from Elsa U. Pardee Foundation titled “A Targeted Activation and Intracellular Delivery System for Anticancer Agents” for the period of 7/1/2007-6/30/2008.

Professor Longqin Hu received a grant from National Cancer Institute (R03 CA125868) titled “Novel Keap1-Nrf2 Inhibitors as Chemopreventive Agents” for the period of 7/1/2007-6/30/2009.

Professor Xumu Zhang was an invited speaker at the 3rd International Conference on Green and Sustainable Chemistry, July 1 - 5, 2007, Delft, Netherlands.

June

The Department of Pharmaceutical Chemistry is co-sponsoring the 2007 Tristate Chinese American Chemical Society Annual Symposium on June 16 at Rutgers University, Piscataway, NJ. Please register on-line at http://www.tristatecacs.org/, or via email at info@tristatecacs.org. Registration on-site is accepted but you are encouraged to register before hand so we can plan the event better. For more information, please contact Longqin Hu @ 732-445-5291, Xiaoqiu Wu @ 609-240-9200, or Sunny Wang @ 908-231-3648.
Symposium Announcement
Symposium Program

Congratulations to two of our graduate students, Diandian Shen and Cara Welch, working under the direction of Professor James Simon in the area of natural products chemistry, on receiving travel grants from the American Society of Pharmacognosy to attend the ASP meeting and botanical standardization workshop in Maine this July. They will be presenting results from their research projects at the meeting.

Barbieri, C.M., Srinivasan, A.R., Rzuczek, S.G., Rice, J.E., LaVoie, E.J., and Pilch, D.S. Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA. Nucleic Acids Res., 35(10), 3272-3286, 2007.

April

US Patent # 7,208,492 was awarded to Edmond J. LaVoie, Alex Ruchelman, and Leroy Liu, Topoisomerase-Targeting Agents on April 24th, 2007, . This patent is among those licensed by Genzyme.

A US patent application titled "Therapeutic Compounds" was filed on April 25, 2007 by Edmond J. LaVoie, Joseph E. Rice, and Leroy Liu.

February

Dr. Xumu Zhang, from Penn State University, has joined the Medicinal Chemistry Department at Rutgers University as Professor II of Medicinal Chemistry. Professor Zhang and his group are in the process of moving into their newly renovated laboratories on the 3rd floor of the Ernest Mario Schoool of Pharmacy.

Xinghua Wu and Longqin Hu, Efficient amidation from carboxylic acids and azides via selenatriazoline: application to the coupling of amino acids and peptides with azides. J. Org. Chem., 72(3), 765-774, 2007.

Yongying Jiang and Longqin Hu, Phenylalanyl-aminocyclophosphamides as model prodrugs for proteolytic activation: synthesis, stability, and stereochemical requirements for enzymatic cleavage. Bioorg. Med. Chem. Lett., 17(2), 517-521, 2007.