Medicinal Chemistry
News and Events - 2005


December

Raghavendra S. Navath, Kumar B. Pabbisetty, and Longqin Hu Chemoselective deprotection of N-Boc group in amino acids and peptides by bismuth (III) trichloride. Tetrahedron Lett. 2006, 47(3), 389-393.

Dr. Longqin Hu chaired the local organizing committee and medicinal chemistry session for the Biopharm 2005 Annual Conference on Tackling the Challenges in Drug Research, Development and Commercialization, a conference cosponsored by The Ernest Mario School of Pharmacy and the Biopharm Division of the Society of Chinese Bioscientist in America (SCBA) and held in Busch Campus Center, Piscataway, NJ on December 4th, 2005.

Dr. Edmond J. LaVoie presented a talk entitled Novel Non-Camptothecin Topoisomerase I-Targeting Anticancer Agents at the Biopharm 2005 Annual Conference on Tackling the Challenges in Drug Research, Development and Commercialization, held at the Busch Campus Center, Piscataway, NJ on December 4th, 2005.

November

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents, Shejin Zhu, Alexander L. Ruchelman, Nai Zhou, Angela A. Liu, Leroy F. Liu and Edmond J. LaVoie, Bioorganic and Medicinal Chemistry 13(24), 6782-6794, 2005.

A patent was issued to Dr. Edmond J. LaVoie, "Topoisomerase Poison Agents" US Patent 6964965, Issued November 15, 2005.

October

Professor Edmond J. LaVoie was invited to present the opening plenary lecture at the Mainzer Forum at the University of Mainz in Germany on October 5, 2005. This was organized by the Institute for Pharmacy at Johannes Gutenberg University within Mainz University and immediately preceded the Annual Meeting of the German Pharmaceutical Society.

Xinghua Wu and Longqin Hu, Amide Bond Formation from Selenocarboxylates and Aromatic Azides. Tetrahedron Letters 2005, 46(28), 8401-8405.

July

Professor Longqin Hu presented a talk entitled "Anticancer Prodrugs Designed to Target Tumor Cells" at Frontiers of Organic and Bioorganic Chemistry: A Conference of Chinese-US Chemists, held on June 13-14th, 2005 at the College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, China. He also presented that same lecture at the Soochow University School of Pharmacy, Suzhou, China on June 22 and at the Second Military Medical University School of Pharmacy, Shanghai, China on June 27, 2005.

June

Alexander L. Ruchelman, Nai Zhou, Angela Liu, Leroy F. Liu, and Edmond J. LaVoie 5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-Alkyl Substituents Modulates Sensitivity to Efflux Transport Associated with Multidrug Resistance, J. Med. Chem., 48, 792-804, 2005.

Professor Edmond LaVoie has been appointed by the "Ministry of Training, Colleges and Universities in Ontario, Canada" to assess the quality of a newly instituted B.S. Program in Pharmaceutical Chemistry at the University of Ontario Institute of Technology

Professor Joseph E. Rice has been appointed to the Executive Council of the Graduate School, New Brunswick for the 2005-2006 academic year.

April

The Medicinal Chemistry Department has just purchased and installed an Advanced ChemTech Model 90 Peptide Synthesizer to be used as shared instrumentation by all research groups

January

Joshua D. Lambert, Joseph E. Rice, Jungil Hong, Zhe Hou, and Chung S. Yang, "Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives", Bioorganic and Medicinal Chemistry Letters 15(4) 873-876, 2005