Graduate Program in Medicinal Chemistry

 

S. David Kimball

Senior Vice President for Discovery
Chemistry and Preclinical Chemical Development
 
Pharmacopeia
Ph.D., 1982, S.U.N.Y. at Stony Brook
Phone (609) 452-3744
e-mail dkimball@pcop.com
  

Current Interests:

Inhibition of cyclin-dependent kinases; discovery of mechanism-based anticancer drugs. Discovery of novel agents that modulate ion flux across cell membranes for the treatment of hypertension, myocardial ischemia, arrhythmia, and other cardiovascular problems, enzymes of the blood coagulation cascade and their relevance to thrombosis and hemostasis.


Recent publications (representative):

S. David Kimball and Kevin R. Webster (2001) Cell Cycle Kinases and Checkpoint Control in Cancer, Annual Reports in Medicinal Chemistry 36: In press.

K. Webster, S. D. Kimball (2000) Novel Drugs Targeting the Cell Cycle, Emerging Drugs 5: 45-59.

S. D. Kimball (1999) Oral Thrombin Inhibitors: Challenges and Progress in Handbook of Experimental Pharmacology Vol. 132, Chapter 13,  Springer Verlag, Berlin.

V. Degtiar, F. Döring, S. Actél, E. N. Timin, S, Berjukow, S.D. Kimball, J. Mitterdorfer, H.I. Glossmann, S. Hering (1997) Calcium Channel Block by (-) Devapamil is Affected by the Sequence Environment and Composition of the Phenylalkylamine Receptor Site, Biophysical Journal, 73: 157-167.

T. Brauns, H. Prinz, S.D. Kimball, R. P. Haugland, J. Striessnig, H. Glossmann (1997) L-type calcium channels: Binding Domains for Dihydropyridines and Benzothiazepines are Located in Close Proximity to Each Other, Biochemistry, 36: 3625-3631.

R. Kraus, B, Reichl, S.D. Kimball, M. Grabner, W, A. Catterall, J. Striessnig (1996). Identification of Benz(othi)azepine Binding Regions within L-type Calcium Channel Alphal Subunits. Journal of Biological Chemistry, 271: 20113-20118.

S.D. Kimball (1995) Thrombin Active Site Inhibitors, Current Pharmaceutical Design, 1: 441-468.

S.D. Kimball (1995) Review of The Design of Synthetic Thrombin Inhibitors, Quarterly Review Biology, 70: 373-374.

S.D. Kimball (1995) Challenges in the Development of Orally Bioavailable Thrombin Active Site Inhibitors, Blood Coagulation and Fibrinolysis, 6: 511-519.

J. Das, S.D. Kimball (1995) Thrombin Active Site Inhibitors, Bioorg. Med. Chem., 3: 999-1007.

T, Brauns, Z.-W. Cai, S.D. Kimball, H-C. Kang, R. P. Haugland, W. Berger, S. Berjukov, S. Berjukov, H. Glossmann, J. Striessnig (1995) The Benzothiazepinone Binding Domain of Purified L-type Calcium Channels: Direct Labeling Using a Novel Fluorescent Diltiazem Analogue, Biochemistry, 34: 3461-3469.

G, C. Rovnyak, S.D, Kimball, B. Beyer, G. Cucinotta, J. D. DiMarco, J. Z. Gougoutas, A, Hedberg, M. Malley, J. P. McCarthy, R. Zhang, S. Moreland (1995) Calcium Entry Blockers and Activators; Conformational and Structural Determinants of Dihydropyrimidine, Calcium Channel Modulator.e Chem., 38: 119-129.