Spring 2014

Instructors

Invited Serminar Speakers

Course Announcements


Course Description

The Principles of Drug Design course aims to provide students with an understanding of the process of drug discovery and development from the identification of novel drug targets to the introduction of new drugs into clinical practice. It covers the basic principles of how new drugs are discovered with emphasis on lead identification, lead optimization, classification and kinetics of molecules targeting enzymes and receptors, prodrug design and applications, as well as structure-based drug design methods. Recent advances in the use of computational and combinatorial chemistry in drug design will also be presented. The course is further enhanced with invited lectures on recent developments and applications of drug design principles in the pharmaceutical industry.

Examinations

A term paper, computational project(s), and two exams

Grading

Term paper on a drug target with 5 drug design principles 20%
Computational project(s) 20%
Exam 1 on approaches to drug discovery (analog design), enzymes, receptors, prodrugs, and combinatorial chemistry 30%
Exam 2 on CADD and seminars 30%
Total 100%

To check your grades during the semester, please go to Sakai.

Course Material

Useful Links

  • Literature Search Links
  • Alphabetical List of Chemistry Journals - A list of almost 700 links to chemistry magazines and journals
  • Alphabetical List of Biochemistry, Cell and Molecular Biology Journals
  • Alphabetical List of Journal Abbreviations
  • Cambridge University Chemical Laboratory - Chemistry Journals
  • Electronic Journals Links - Chemistry -Los Alamos National Laboratory
  • New Jour - the Internet list for new journals and newsletters available on the Internet (a list of electronic journals on the Internet, not restricted to just science)
  • Drug discovery & development Glossary
  • Glossary of terms used in medicinal chemistry- IUPAC -Pure Appl. Chem., 70, 1129-1143 (1998)
  • Glossary of terms used in combinatorial chemistry (pdf file) - J.Comb.Chem.2000,2,562-578 or PureAppl.Chem.1999,71(12),2349-2365.
  • Modern Drug Discovery

  • Longqin Hu · Rutgers University School of Pharmacy · Department of Medicinal Chemistry