• Dr. Longqin Hu (Course coordinator)
• Dr. David Kimball
• Dr. John Kerrigan (CINJ)
• Dr. Qun Sun (Discovery ChemScience)

Invited Serminar Speakers

• Dr. Zhoupeng Zhang (Merck)
• Dr. David Floyd (Rutgers, Pharmacopeia, BMS)
• Dr. Ashwinikumar Gavai (BMS)
• Dr. Louis Lombardo (Roche)
• Dr. Robert Borzilleri (BMS)
• Dr. Christopher Molloy (Interim Provost and Professor, Rutgers)

• Class Normally Meets on Mondays and Wednesdays, 5:00 - 6:20 pm, PH-007 (1st lecture 01/18/2012)
• Metabolic ID and Profiling in Drug Design
  Dr. Zhoupeng Zhang (Merck Research Laboratory), 5:00 - 6:20 pm, PH-007, Wednesday, February 15, 2012
• Discovery of New Antimalarial Agetns
  Dr. David Floyd (Rutgers Chemistry Department and former Executive Vice President of Discovery and Chief Scientific Officer at Pharmacopeia and vice president of Discovery Research at Bristol-Myers Squibb), 5:00 - 6:20 pm, PH-007, Monday, February 20, 2012
• Discovery of Androgen Receptor Antagonists
  Dr. Ashvinkumar Gavai (Bristol-Myers Squibb), 5:00 - 6:20 pm, PH-007, Wednesday, February 22, 2012
• Case Studies on Kinase Inhibitors
  Dr. Lou Lombardo (Roche), 5:00 - 6:20 pm, PH-007, Monday, March 5, 2012
• Discovery of Ixabepilone
  Dr. Robert Borzilleri (Bristol-Myers Squibb), 5:00 - 6:20 pm, PH-007, Wednesday, March 7, 2012
• The Drug Discovery and Development Process
  Dr. Christopher Molloy, Dean of Ernest Mario School of Pharmacy, 5:00 - 6:20 pm, PH-007, Wednesday, April 25, 2012

Course Description

The Principles of Drug Design course aims to provide students with an understanding of the process of drug discovery and development from the identification of novel drug targets to the introduction of new drugs into clinical practice. It covers the basic principles of how new drugs are discovered with emphasis on lead identification, lead optimization, classification and kinetics of molecules targeting enzymes and receptors, prodrug design and applications, as well as structure-based drug design methods. Recent advances in the use of computational and combinatorial chemistry in drug design will also be presented. The course is further enhanced with invited lectures on recent developments and applications of drug design principles in the pharmaceutical industry.

Examinations

A term paper, computational project(s), and two exams

Grading

Term paper on a drug target with 5 drug design principles	20%
Computational project(s)	20%
Exam 1 on approaches to drug discovery (analog design), enzymes, receptors, and prodrugs	30%
Exam 2 on computational, combinatorial chemistry, and seminars	30%
Total	100%

To check your grades during the semester, please go to Sakai.

Course Material

• Class Schedule (pdf file)
• Course Syllabus (pdf file)

  References:

• Bioisosterism: A Rational Approach in Drug Design, G. A. Patani and E.J. LaVoie, Chem. Rev. 1996, 96, 3147-3176.
• The Chemistry of ADEMT M. S. Lesney Today's Chemist at Work 2004, 13(1), 27-30.
• Enzyme Nomenclature - Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Useful Links